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ANTISENSE PHOSPORODIAMIDATE MORPHOLINO OLIGONUCLEOTIDE INHIBITION OF CYTOCHROME P450 TO MODULATE DRUG PHARMACOKINETICS
ANTISENSE PHOSPORODIAMIDATE MORPHOLINO OLIGONUCLEOTIDE INHIBITION OF CYTOCHROME P450 TO MODULATE DRUG PHARMACOKINETICS
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机译：抗磷脂酰二氨基吗啡低聚核苷酸抑制细胞色素P450调节药物药代动力学
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摘要
A method is described for improving the pharmacokinetics of a drug in asubject, by co-administering oligomers, preferably PMO's (phosphorodiamidatemorpholino oligonucleotides), antisense to RNAs encoding drug-metabolizingenzymes, particularly p450 enzymes. The oligomers reduce production of thedrug-metabolizing enzymes, which extends drug half-life and effectivenessand/or decreases drug toxicity.
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