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首页> 外国专利> DRY POWDER INHALATION SYSTEM, LYOPHILIZED COMPOSITION, DRY POWDER INHALER (VARIANTS), PROCESS FOR PRODUCING DRY POWDER-LIKE PREPARATION FOR TRANSPULMONARY ADMINISTRATION, METHOD OF TRANSPULMONARY ADMINISTRATION, USE OF LYOPHILIZED COMPOSITION FOR TRANSPULMONARY ADMINISTRATION BY INHALATION (VARIANTS)

DRY POWDER INHALATION SYSTEM, LYOPHILIZED COMPOSITION, DRY POWDER INHALER (VARIANTS), PROCESS FOR PRODUCING DRY POWDER-LIKE PREPARATION FOR TRANSPULMONARY ADMINISTRATION, METHOD OF TRANSPULMONARY ADMINISTRATION, USE OF LYOPHILIZED COMPOSITION FOR TRANSPULMONARY ADMINISTRATION BY INHALATION (VARIANTS)

机译：干粉吸入系统，冻干组合物，干粉吸入器（变种），生产干粉样的经皮给药的制备方法，经皮给药的方法，使用经粉化的脂质体成分（经转换）

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摘要

It is intended to provide a novel dry powder inhalation system for transpulmonary administration. This dry powder inhalation system for transpulmonary administration contains a single dose of the active ingredient and is characterized by comprising a combination of a container packed with a freeze-dried composition having the following properties: (i) being in the form of a non-powder cake; (ii) having a decay index of 0.015 or above; and (iii) upon an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec, being disintegrated into fine particles having an average particle diameter of 10 m or below or an effective particle ratio of 10% or above; with a device provided with means of imparting the above air impact to the freeze-dried composition in the above container and means of discharging the powdery freeze-dried composition having been disintegrated into fine particles from the container.
机译：旨在提供用于经肺给药的新型干粉吸入系统。这种用于经肺给药的干粉吸入系统包含单剂量的活性成分，其特征在于包括装有装有下列特性的冻干组合物的容器的组合：（i）非粉末形式蛋糕; （ii）衰减指数为0.015或以上; （iii）在空气速度至少为1 m / sec，空气流速至少为17 ml / sec的空气冲击下分解成平均粒径为10μm或以下的细颗粒或有效粒子比率为10％或以上;本发明的目的是提供一种装置，该装置具有对上述容器中的冻干组合物施加上述空气冲击的装置，以及从容器中排出已分解成细颗粒的粉状冻干组合物的装置。

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