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ANTIBODIES BINDING TO HUMAN MAGIC ROUNDABOUT (MR), POLYPEPTIDES AND USES THEREOF FOR INHIBITION OF ANGIOGENESIS
ANTIBODIES BINDING TO HUMAN MAGIC ROUNDABOUT (MR), POLYPEPTIDES AND USES THEREOF FOR INHIBITION OF ANGIOGENESIS
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机译:结合至人类神奇圆形抗体(MR),多肽的抗体及其用于抑制血管生成的用途
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摘要
A method of inhibiting angiogenesis in an individual in need thereof comprising administering an antibody that selectively binds to the extracellular region of human magic roundabout (MR) to the individual. An antibody that has the amino acid sequences i) to iii), the amino acid sequences iv) to vi), or the amino acid sequences i) to vi). i) S A S S S V S Y M Y ii) L T S N L A S iii) Q Q W S S N P L T iv) D Y N L N v) V I N P N Y G T T S Y N Q K F K G vi) G R D Y F G Y. A method of inhibiting angiogenesis in an individual in need thereof comprising administering the extracellular domain (residues 1-467) of MR, or a fragment thereof that inhibits angiogenesis, to the individual. A method of inhibiting endothelial cell migration and/or proliferation comprising administering the extracellular domain of MR, or a fragment thereof that inhibits endothelial cell migration and/or proliferation.
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