首页> 外国专利> 1. Used in the production of ethylene oxide (1s, 3S, 7S, 10R, 11S, 12s, 16r) 7, 11hydroxi-3 - (2-methyl-benzodiazepine-5-il) - 10 - (prop-2-1-il) - 8, 8-12, 16-tetramethyl-4, 17dioxabicyclo 14.1.0 hetade can-5, 9-diona

1. Used in the production of ethylene oxide (1s, 3S, 7S, 10R, 11S, 12s, 16r) 7, 11hydroxi-3 - (2-methyl-benzodiazepine-5-il) - 10 - (prop-2-1-il) - 8, 8-12, 16-tetramethyl-4, 17dioxabicyclo 14.1.0 hetade can-5, 9-diona

机译：1.用于生产环氧乙烷（1s，3S，7S，10R，11S，12s，16r）7，11hydroxi-3-（2-methyl-benzodiazepine-5-il）-10-（prop-2-1 -il）-8，8-12，16-四甲基-4，17dioxabicyclocyclo [14.1.0] hetade can-5，9-diona

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REFERRED TO A METHOD FOR PRODUCING A COMPOSITION THAT INCLUDES AN EPOTILONE, WHERE THIS PROCESS CONSISTS OF: a) DISSOLVING (1S, 3S, 7S, 10R, 11S, 12S, 16R) -7,11-DIHIDROXI-3- (2-METHYL -BENZOTIAZOLE-5-IL) -10- (PROP-2-EN-1-IL) -8,8,12,16-TETRAMETIL-4,17-DIOXABICICLO [14.1.0] HEPTADECAN-5,9-DIONA IN AN ORGANIC SOLVENT SUCH AS ETHANOL, b) EVAPORATE SUCH AN ORGANIC SOLVENT, c) SOLVING HYDROXIPROPIL-BETA-CYCLODEXTRINE IN AQUEOUS SOLUTION, d) ADJUSTING THE pH OF THE RESULTING MIXTURE IN b) BETWEEN 5 AND 9, SOLVING THE POWDER b) IN THE SOLVENTS RESULTING FROM c) OR d) AND THEN PERFORM A STERILE FILTRATION TO OBTAIN A SOLUTION FROM WHICH THE SOLVENT IS REMOVED AND A SOLID PRODUCT IS OBTAINED

机译：涉及一种制备包含依托匹隆的组合物的方法，该方法由以下步骤组成：a）溶解（1S，3S，7S，10R，11S，12S，16R）-7,11-二氢己基-3-（2-甲基） -BENZOTIAZOLE-5-IL）-10-（PROP-2-EN-1-IL）-8,8,12,16-TETRAMETIL-4,17-DIOXABICICLO [14.1.0] HEPTADECAN-5,9-DIONA IN有机溶剂，如乙醇，b）蒸发后的有机溶剂，c）在水溶液中溶解羟丙基-贝他-环糊精，d）调节b）所得混合物的pH，b）在5和9之间，将粉末c）或d）产生的溶剂，然后进行灭菌过滤以获取去除溶剂和获得固体产品的解决方案

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公开/公告号PE20100240A1

专利类型
公开/公告日2010-05-02

原文格式PDF
申请/专利权人 BAYER SCHERING PHARMA AKTIENGESELLSCHAFT;
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申请/专利号PE2010000026
发明设计人 REER OLAF;RENZ MATTHIAS;SACHSE ANDREAS;SPRENGER CLAUDIA;THOMSEN JENS;UFFRECHT ANKA;
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申请日2006-01-03
分类号A61K31/429;A61K9;A61K47/40;
国家 PE
入库时间 2022-08-21 18:45:22

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