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Reaction of 2-chloro-8-benzyloxyquinoline with 2-nitrophenylamine in the presence of 1,2-bis(diphenylphosphino)ethane (dppe), palladium catalyst and a base
Reaction of 2-chloro-8-benzyloxyquinoline with 2-nitrophenylamine in the presence of 1,2-bis(diphenylphosphino)ethane (dppe), palladium catalyst and a base
Disclosed is a process for preparing (8-benzyloxy-quinolin-2-yl)-[4-(3-methyl-oxetan-3-ylmethoxy)-2-nitro-phenyl]-amine, the process comprising reacting about 1.2 equivalents of 4-(3-methyl-oxetan-3-ylmethoxy)-2-nitro-phenylamine with about 1 equivalent of 8-benzyloxy-2-chloroquinoline in the presence of about 0.06 equivalents of 1,2-bis(diphenylphosphino)ethane, about 0.02 equivalents of palladium acetate; about 1.4 equivalents of cesium carbonate, and toluene. (62) Divided Out of 543714
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