首页> 外国专利> ORALLY DISINTEGRATING PHARMACEUTICAL COMPOSITIONS OF ESCITALOPRAM AND SALTS THEREOF

ORALLY DISINTEGRATING PHARMACEUTICAL COMPOSITIONS OF ESCITALOPRAM AND SALTS THEREOF

机译:欧佩克的口头可分解药物成分及其盐

摘要

An orally disintegrating pharmaceutical composition comprising Escitalopram or salts thereof as an active ingredient; diluent (s) selected from the group consisting of cellulose derivatives such as microcrystalline cellulose and the like, mannitol, lactose, dextrose, sorbitol, starch, xylitol, maltose, dicalcium phosphate and their derivatives thereof; disintegrating agent(s) and optionally one or more suitable pharmaceutically acceptable excipient(s). A method of manufacturing of an orally disintegrating pharmaceutical composition comprising Escitalopram and/or salts thereof, diluents, disintegrating agents, binders, and solvent (s), to form a wet granulate; drying of wet granulate, to produce a dry granulate comprising the Escitalopram and/or salts thereof; blending of dry granulate with other ingredients, wherein the granules can be filled into a sachet or can be compressed into a dosage form.
机译:包含艾司西酞普兰或其盐作为有效成分的口腔内崩解药物组合物。稀释剂选自纤维素衍生物如微晶纤维素等,甘露醇,乳糖,右旋糖,山梨糖醇,淀粉,木糖醇,麦芽糖,磷酸二钙及其衍生物;崩解剂和任选的一种或多种合适的药学上可接受的赋形剂。一种包含艾司西酞普兰和/或其盐,稀释剂,崩解剂,粘合剂和溶剂的口腔崩解药物组合物的制备方法,以形成湿颗粒。干燥湿颗粒,以产生包含依西酞普兰和/或其盐的干颗粒;将干颗粒与其他成分混合,其中可以将颗粒填充到小袋中或可以压缩成剂型。

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