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RhoB as a suppressor of cancer cell growth, cell transformation, and metastasis

机译:RhoB作为癌细胞生长,细胞转化和转移的抑制剂

摘要

The present invention concerns the use of the protein RhoB and its variants to inhibit cancer cell growth, migration, invasion, metastasis, malignant cell transformation, and/or to modulate oncogenic signaling, wherein introducing RhoB directly, or indirectly via a nucleic acid sequence encoding RhoB, into a malignantly transformed cell or a cancerous cell decreases phosphorylation of Erk and Akt proteins inhibiting the PI3-kinase/Akt cell survival pathway and promoting apoptotic cell death. In one aspect, the compositions and methods of the present invention are used to inhibit the malignant transformation of cells by the oncogenes H-Ras, N-Ras, K-Ras, EGFR, or ErbB2, or to inhibit the growth of cancer cells transformed by such oncogenes. The compositions and methods of the present invention may be used to inhibit cancer cell growth, inhibit malignant cell transformation, and modulate oncogenic signaling in vivo or in vitro.
机译:本发明涉及蛋白质RhoB及其变体在抑制癌细胞生长,迁移,侵袭,转移,恶性细胞转化和/或调节致癌信号中的用途,其中直接或通过编码核酸的核酸序列间接引入RhoB RhoB进入恶性转化细胞或癌细胞会降低Erk和Akt蛋白的磷酸化,从而抑制PI3激酶/ Akt细胞存活途径并促进凋亡性细胞死亡。一方面,本发明的组合物和方法用于抑制癌基因H-Ras,N-Ras,K-Ras,EGFR或ErbB2对细胞的恶性转化,或用于抑制转化的癌细胞的生长。通过这种致癌基因。本发明的组合物和方法可用于在体内或体外抑制癌细胞生长,抑制恶性细胞转化和调节致癌信号。

著录项

  • 公开/公告号US7629310B2

    专利类型

  • 公开/公告日2009-12-08

    原文格式PDF

  • 申请/专利权人 SAID M. SEBTI;

    申请/专利号US20060512563

  • 发明设计人 SAID M. SEBTI;

    申请日2006-08-30

  • 分类号A61K38/00;A61K38/16;A61K38/17;C07K14/00;C07K14/47;

  • 国家 US

  • 入库时间 2022-08-21 18:47:43

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