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Immunizing compositions comprising recombinant attenuated self-replicating viral RNA replicons encoding an epitope obtained from the HIV-1 matrix protein myrstate binding site
Immunizing compositions comprising recombinant attenuated self-replicating viral RNA replicons encoding an epitope obtained from the HIV-1 matrix protein myrstate binding site
The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one covalent binding site of myristate (SEQ ID NOS: 1-3) on the HIV matrix protein. The present invention contemplates three categories of embodiments: protein or protein fragments (SEQ ID NO: 1), messenger RNA, or DNA/RNA (SEQ ID NOS:2-3). DNA/RNA compositions may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.
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机译：本发明涉及免疫原性组合物。更具体地，本发明是针对引起对HIV基质蛋白上的肉豆蔻酸酯的至少一个共价结合位点（SEQ ID NOS：1-3）的免疫应答的组合物。本发明考虑了三类实施方案：蛋白质或蛋白质片段（SEQ ID NO：1），信使RNA或DNA / RNA（SEQ ID NOS：2-3）。 DNA / RNA组合物可以是裸露的或重组的。本发明进一步考虑与多种免疫刺激剂一起使用。
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