首页> 外国专利> Use of outer membrane protein A (OMPA) in treatment/prevention/diagnosis of infections caused by Klebsiella pneumoniae and other gram-negative bacteria

Use of outer membrane protein A (OMPA) in treatment/prevention/diagnosis of infections caused by Klebsiella pneumoniae and other gram-negative bacteria

机译：外膜蛋白A（OMPA）在治疗/预防/诊断肺炎克雷伯氏菌和其他革兰氏阴性细菌引起的感染中的用途

展开▼

页面导航

摘要

著录项

相似文献

摘要

The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. 展开▼

机译：本发明提供了通过给予有效量来治疗和/或预防哺乳动物中枢神经系统和/或外周血循环中由肺炎克雷伯氏菌和其他革兰氏阴性细菌引起的细菌感染的方法。外膜蛋白A（OmpA）或其衍生物对哺乳动物的作用。还提供了给哺乳动物接种疫苗以产生针对中枢神经系统和/或外周血循环中肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由引起的细菌感染的方法。哺乳动物中肠杆菌科家族。 展开▼

著录项

公开/公告号US7807139B2

专利类型

公开/公告日2010-10-05

原文格式PDF

申请/专利权人 YI-YUAN YANG;HSUEH-HSIA WU;SY-JYE LEU;NENG-YAO SHIH;I-JEN HUANG;CHING-YU LIN;WEN-SHYANG HSIEH;KO-JIUNN LIU;SHIH-YI HUANG;YUEH-LUN LEE;CHI-HSIN LEE;YUAN-SOON HO;SHIH-LAN HSU;
展开▼

申请/专利号US20090359205

发明设计人 YI-YUAN YANG;HSUEH-HSIA WU;SY-JYE LEU;NENG-YAO SHIH;I-JEN HUANG;CHING-YU LIN;WEN-SHYANG HSIEH;KO-JIUNN LIU;SHIH-YI HUANG;YUEH-LUN LEE;CHI-HSIN LEE;YUAN-SOON HO;SHIH-LAN HSU;
展开▼

申请日2009-01-23

分类号A61K49;A61K39;A61K39/108;

国家 US

入库时间 2022-08-21 18:49:23

相似文献

专利

外文文献

中文文献

1. 蛋白及其组合物与在制备预防、诊断或治疗EHEC感染产品中的应用 [P] . 中国专利： CN103212060B . 2014.11.05

2. 蛋白及其组合物与在制备预防、诊断或治疗EHEC感染产品中的应用 [P] . 中国专利： CN103212060A . 2013-07-24

3. USE OF OUTER MEMBRANE PROTEIN A (OMPA) IN TREATMENT/PREVENTION/DIAGNOSIS OF INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE AND OTHER GRAM-NEGATIVE BACTERIA [P] . 美国专利： US2009232852A1 . 2009-09-17

机译：外膜蛋白A（OMPA）在肺炎克雷伯菌和其他革兰氏阴性菌引起的感染的治疗/预防/诊断中的用途

4. Polypeptide from the outer membrane of Chlamydia pneumoniae, fragments thereof and their uses, particularly for the diagnosis, prevention and treatment of a polypeptide infection of the outer membrane of Chlamydia pneumoniae, fragments thereof and their uses, particularly for the diagnosis, prevention and treatment of an infection. [P] . ES2352082T3 . 2011-02-15

机译：来自肺炎衣原体的外膜的多肽，其片段及其用途，特别是用于诊断，预防和治疗肺炎衣原体的外膜的多肽感染，其片段及其用途，特别是用于肺炎衣原体的诊断，预防和治疗感染。

5. CYCLIC PEPTIDES AGAINST THE OUTER MEMBRANE PROTEIN A (OMPA) FOR THE TREATMENT OF INFECTIONS CAUSED BY GRAM NEGATIVE PATHOGENS [P] . 世界知识产权组织专利： WO2016046397A1 . 2016-03-31

机译：对抗外膜蛋白A（OMPA）的环肽，用于治疗革兰氏阴性病原体引起的感染

1. Development and Evaluation of a MAb-Based ELISA for Detection of Chlamydophila pneumoniae Infection with Variable Domain 2 and 3 of the Major Outer Membrane protein [J] . ZHOU Zhou, WU Yi Mou, CHEN Li Li, 生物医学与环境科学（英文版） . 2012,第006期

2. Major heat-modifiable outer membrane protein in gram-negative bacteria: comparison with the ompA protein of Escherichia coli. [J] . M G Beher, C A Schnaitman, A P Pugsley Journal of bacteriology . 1980,第2期

3. Multi-drug carbapenem-resistant Klebsiella pneumoniae infection carrying the OXA-48 gene and showing variations in outer membrane protein 36 causing an outbreak in a tertiary care hospital in Riyadh, Saudi Arabia [J] . Taher uz Zaman, Mohammed Aldrees, Sameera M. Al Johani, International journal of infectious diseases : . 2014,第Supplementa1期

4. Enhancement of uptake of lipopolysaccharide in macrophages by the major outer membrane protein OmpA of gram-negative bacteria. [J] . A Korn, Z Rajabi, B Wassum, Infection and immunity . 1995,第7期

5. Efficacy and Safety of Polymyxin B in the Treatment of Infections Caused by Multidrug- Resistant Gram-Negative Infections: A Retrospective Review [C] . Oh HML, Gan LH, Wee I International Congress of Chemotherapy and Infection . 2009

6. Immunotherapy Improves Outcomes by Ameliorating Inflammation during Infections Caused by Gram-Negative Bacteria [D] . Nielsen, Travis Brady. 2018

7. Major heat-modifiable outer membrane protein in gram-negative bacteria: comparison with the ompA protein of Escherichia coli. [O] . M G Beher, C A Schnaitman, A P Pugsley 1980

8. The C-terminal sequence conservation between OmpA-related outer membrane proteins and MotB suggests a common function in both Gram-positive and Gram-negative bacteria, possibly in the interaction of these domains with peptidoglycan [O] . De Mot René, Vanderleyden Jozef 1994

9. Inflammatory Response of LPS-Hyporesponsive and LPS-Responsive Mice to Challenge with Gram-Negative Bacteria Salmonella typhimurium and Klebsiella pneumoniae. [R] . MacVittie, T. J., O'Brien, A. D., Walker, R. I., 1982

1. Diagnosis of Helicobacterpyloriinfection and diseases associated with Helicobacter pylori by Helicobacter pylori outer membrane proteins [J] . ZhengJiang ,Ai-LongHuang ,Xiao-HongTao . 世界胃肠病学杂志：英文版 . 2004,第23期

2. Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients [J] . Elisabeth Paramythiotou1 ,Christina Routsi2 . 世界重症医学杂志 . 2016,第002期

3. Recombinant outer membrane protein F-B subunit of LT protein as a prophylactic measure against Pseudomonas aeruginosa burn infection in mice [J] . Hassan Heydari Farsani ,Iraj Rasooli ,Seyed Latif Mousavi Gargari . 世界方法学杂志 . 2015,第4期

4. Treatment of Donor-derived Carbapenem-resistant Klebsiella pneumoniae Infection after Renal Transplantation with Tigecycline and Extended-infusion Meropenem [J] . Zhi-qiang WANG ,Zhi-liang GUO ,Hao FENG . 华中科技大学学报（医学）（英德文版） . 2021,第004期

5. 鸭致病性大肠杆菌的外膜蛋白型及外膜蛋白基因A(ompA)的序列分析 [C] . . 中国畜牧兽医学会动物微生态学分会第四届第九次全国学术研讨会暨饲料和动物源食品安全战略论坛 . 2008

6. 禽致脑膜炎型大肠杆菌外膜蛋白OmpA突破血脑屏障致病机制的研究 [A] . 许姝 . 2020