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Avidin dimers effective in increasing the concentration of radioactive biotin in pretargeted radioimmunotherapy
Avidin dimers effective in increasing the concentration of radioactive biotin in pretargeted radioimmunotherapy
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机译：抗生物素蛋白二聚体可有效提高预靶向放射免疫疗法中放射性生物素的浓度
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摘要
Dimers of avidin and streptavidins (diavidins) are described wherein the linker is suberate, which in turn, is bound to different functional groups (—NH2 o-COOH) of avidin. As compared to avidin, the diavidins have shown the ability to increase the amount of labelled biotin on the target, when used in an in vitro pretargeting test using supported human tenascin, the biotinylated anti-tenascin monoclonal antibody (Mab-B), avidin/diavidin, and biotin-3H. The use of such diavidins is also described in cancer diagnosis and anticancer therapy based on the three-step pretargeted radioimmunotherapy procedure.
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