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首页> 外国专利> Method and composition for leucyl-tRNA synthetases and derivatives thereof that activate and aminoacylate non-leucine amino acid to tRNA adaptor molecules

Method and composition for leucyl-tRNA synthetases and derivatives thereof that activate and aminoacylate non-leucine amino acid to tRNA adaptor molecules

机译：用于将非亮氨酸氨基酸活化并氨酰化为tRNA衔接子分子的亮氨酰tRNA合成酶及其衍生物的方法和组合物

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A method and composition for tRNA synthetases that activate and aminoacylate nonstandard and noncognate amino acids to tRNA adaptor molecules is described that can be used to generate custom designed protein products for uses in medicinal, therapeutic, diagnostic, biotechnology, engineering, and spectroscopy applications. Some tRNA synthetases naturally misactivate and misaminoacylate noncognate amino acids. Many of these tRNA synthetases, including but not limited to leucyl-, isoleucyl-, and valyl-tRNA synthetases, have evolved proofreading and editing mechanisms to correct these mistakes. Inactivation of the enzyme's editing activity allows and facilitates production and accumulation of tRNAs that are misaminoacylated with nonstandard and noncognate amino acids. These misaminoacylated tRNAs can be used to introduce novel amino acids into proteins.
机译：描述了一种tRNA合成的方法和组合物，该方法和组合物可将非标准和非同源氨基酸激活并氨酰化为tRNA衔接子分子，可用于生成定制设计的蛋白质产品，用于医药，治疗，诊断，生物技术，工程学和光谱学应用。一些tRNA合成酶天然使非同源氨基酸失活和错氨酰化。这些tRNA合成酶中的许多，包括但不限于亮氨酰，异亮氨酰和缬氨酰tRNA合成酶，已经发展出校对和编辑机制来纠正这些错误。酶编辑活性的失活允许并促进被非标准和非同源氨基酸误氨酰化的tRNA的产生和积累。这些误氨基酰化的tRNA可用于将新的氨基酸引入蛋白质。

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