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6-aminoimidazo1,2-bpyridazine analogs as rho kinase inhibitors for the treatment of rho kinase-mediated diseases and conditions

机译：6-氨基咪唑并[1,2-b]哒嗪类似物作为rho激酶抑制剂，用于治疗rho激酶介导的疾病和状况

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摘要

Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of 6-aminoimidazo[1,2-b]pyridazine analogs, are disclosed herein.

机译：本文公开了使用6-氨基咪唑并[1,2-b]哒嗪类似物来治疗rho激酶介导的疾病或rho激酶介导的疾病的方法，包括控制眼内压和治疗青光眼。本文公开了用于治疗眼疾病例如青光眼并且另外可用于控制眼内压的眼科药物组合物，所述组合物包含有效量的6-氨基咪唑并[1,2-b]哒嗪类似物。

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公开/公告号US7820670B2

专利类型
公开/公告日2010-10-26

原文格式PDF
申请/专利权人 HWANG-HSING CHEN;ANDREW RUSINKO;MARK R. HELLBERG;BRYON S. SEVERNS;ALAN J. HENDERSON;CHENG GUO;MARK HADDEN;
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申请/专利号US20070960476
发明设计人 HWANG-HSING CHEN;ANDREW RUSINKO;MARK R. HELLBERG;BRYON S. SEVERNS;ALAN J. HENDERSON;CHENG GUO;MARK HADDEN;
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申请日2007-12-19
分类号A61K31/501;
国家 US
入库时间 2022-08-21 18:50:49

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