Method of inducing liver phase II enzymes

• 1. 一种诱导人多能干细胞体外分化为停滞在减数分裂II期的卵母细胞的方法 [P] . 中国专利： CN110004112A . 2019-07-12
• 2. 一种利用SUMO融合表达系统制备重组肝素酶III的方法及其所制备的SUMO_肝素酶III融合蛋白 [P] . 中国专利： CN113025598A . 2021-06-25
• 3. Methods for diagnosing induction of liver enzyme, to determine if a compound is capable of inducing the induction of liver enzyme in an individual and to identify a substance for treating liver enzyme induction [P] . BRPI0912175A2 . 2015-10-06

  机译： 诊断肝酶诱导的方法，以确定化合物是否能够在个体中诱导肝酶诱导，并鉴定用于治疗肝酶诱导的物质

• 4. COCKTAIL CULTURE MEDIUM FOR EVALUATING ACTIVITY OF PHASE II DRUG METABOLISM ENZYME ACTIVITY AND DRUG INTERACTIONS AND METHOD FOR HIGH-RATE EVALUATING ACTIVITY OF PHASE II DRUG METABOLISM ENZYME USING SAME [P] . 韩国专利： KR101495860B1 . 2015-02-25

  机译： 用相同的方法评估II相药物代谢酶活性和药物相互作用的鸡尾酒培养基和对2相药物代谢酶进行高效率评估的方法

• 5. PHASE II DETOXIFYING ENZYME INDUCER [P] . 日本专利： JP2008115090A . 2008-05-22

  机译： 第二阶段解毒酶诱导剂

• 1. Gd-EOB-DTPA-enhanced magnetic resonance imaging for focal liver lesions in Chinese patients:a multicenter, open-label, phase III study [J] . Meng-Su Zeng, Hui-Yi Ye, Liang Guo, 国际肝胆胰疾病杂志（英文版） . 2013,第006期
• 2. Nrf2-regulated phase-II detoxification enzymes and phase-III transporters are induced by thyroid hormone in rat liver [J] . Pamela Cornejo, Romina Vargas, Luis A. Videla BioFactors . 2013,第5期
• 3. INFLUENCE OF CLOUDY APPLE JUICE ON N-NITROSODIETHYLAMINE-INDUCED LIVER INJURY AND PHASES I AND II BIOTRANSFORMATION ENZYMES IN RAT LIVER [J] . Krajka-Kuzniak Violetta, Szaefer Hanna, Ignatowicz Ewa, Acta Poloniae Pharmaceutica: Durg Research . 2015,第2期
• 4. INFLUENCE OF CLOUDY APPLE JUICE ON N-NITROSODIETHYLAMINE-INDUCED LIVER INJURY AND PHASES I AND II BIOTRANSFORMATION ENZYMES IN RAT LIVER [J] . Krajka-Kuzniak Violetta, Szaefer Hanna, Ignatowicz Ewa, Acta Poloniae Pharmaceutica: Durg Research . 2015,第2期
• 5. Therapeutic effete of Phase II enzyme inducers in Experimental Allergic Encephalomyelitis (EAE) [C] . Mohamed A., Yunus M. Annual Rocky Mountain Bioengineering Symposium . 2012
• 6. Protective function of phase II enzymes in chemically-induced oxidative injury to the central nervous system. [D] . Stakhiv, Timothy M. 2005
• 7. Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification [O] . Ishfaq Muhammad, He Wang, Xiaoqi Sun, 2018
• 8. Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification [O] . Ishfaq Muhammad, He Wang, Xiaoqi Sun, 2018
• 9. Characterization of an ICII82, 780-Induced, Estrogen Receptor (ER)-beta Mediated Apoptotic Pathway in Prostate Cancer Cells and Establishment of (ER)- beta-Regulated Electrophile-Processing Phase II Enzyme Downregulation as a Promotional Factor in Human Prostatic Carcinogenesis [R] . Ho, S. 2001

• 1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 2. Changes in mRNA Expression and Activity of Xenobiotic Metabolizing Enzymes in Livers from Adjuvant-Induced Arthritis Rats [J] . Atsushi Kawase ,Syoko Wada ,Masahiro Iwaki . 药理与制药（英文） . 2013,第6期
• 3. Liver graft preservation methods during cold ischemia phase and normothermic machine perfusion [J] . Konstantin Y Tchilikidi . 世界胃肠外科杂志：英文版（电子版） . 2019,第3期
• 4. Phase Ⅱ enzymes activity induced by curcumin accompanying translocation of Nrf2 and activation of ARE binding activity [J] . YE She-fang WU Yi-hui ZHONG Li-ming HOU Zhen-qing . 毒理学杂志 . 2007,第4期
• 5. 六溴环十二烷对稀有(鮈)鲫肝脏中酶和脑中乙酰胆碱酯酶的诱导 [C] . 张娴 . 第四届全国环境化学学术大会 . 2007
• 6. 大鼠2/3体积肝脏切除诱导肝脏再生引发期差异蛋白质组研究 [A] . 孙言伟 . 2006