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ELECTROLYTE SOLUTION AND METHOD FOR ELECTROLYTIC CO-DEPOSITION OF THIN FILM CALCIUM PHOSPHATE AND DRUG COMPOSITES
ELECTROLYTE SOLUTION AND METHOD FOR ELECTROLYTIC CO-DEPOSITION OF THIN FILM CALCIUM PHOSPHATE AND DRUG COMPOSITES
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机译：薄膜磷酸钙与药物复合物的电解共沉积电解质溶液及方法
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摘要
Disclosed herein are electrolyte solutions and methods for electrolytic co-deposition of calcium phosphate and drug composites. The electrolyte solution may be formed by mixing solutions comprising calcium and phosphate precursors together to form an electrolyte solution. The electrolyte solution can have a water content less than 30 weight percent. The electrolyte solution may comprise a water-soluble non-aqueous solvent. A therapeutic agent, such as water-insoluble drug, is also present in the solution. The electrolyte solution thus formed may be used to co-deposit a calcium phosphate coating and the therapeutic agent on a substrate. One method includes the steps of immersing the substrate in the electrolyte solution and applying an electrical potential to the substrate to thereby cause (i) the calcium and phosphate precursors to electrochemically react with hydroxyl groups on the surface of the substrate and deposit the calcium phosphate coating thereon; and (ii) the therapeutic agent to electrophoretically migrate to the substrate and become co-deposited thereon together with the calcium phosphate coating. The method thus provides a convenient and easily controllable means for depositing thin film calcium phosphate and drug composites on substrates such as implantable medical devices.
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