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STRUCTURING EFFECT OF CHOLESTEROL IN PEG-PHOSPHOLIPID MICELLES, DRUG DELIVERY OF AMPHOTERICIN B, AND COMBINATION ANTIFUNGALS
STRUCTURING EFFECT OF CHOLESTEROL IN PEG-PHOSPHOLIPID MICELLES, DRUG DELIVERY OF AMPHOTERICIN B, AND COMBINATION ANTIFUNGALS
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机译：胆固醇在PEG-磷脂胶束中的结构效应，两性霉素B的药物递送以及组合抗真菌药
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摘要
The disclosure herein relates to embodiments of compositions and methods in connection with polymeric micelles including PEG-phospholipids. Embodiments also relate to the controlled release of pharmaceutical agents in the context of drug delivery. Further disclosed are embodiments of PEG-DSPE/Cholesterol micelle formulations prepared with an antifungal agent, Amphotericin B, with capabilities including slow release of the agent in a deaggregated state. In embodiments, micellar preparations with Amphotericin B are compatible with solubility in aqueous salt solutions, thus allowing for concurrent co-administration of other pharmaceutical agents and/or sodium supplementation. In embodiments, polymeric micelle compositions are employed in combination antifungal therapeutic approaches such as Amphotericin B and other antifungal agents. Also disclosed herein are compositions and methods relating to combinations including AmB:PEG-DSPE, rapamycin:PEG-DSPE, and/or 5-fluorocytosine.
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