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ZWITTERIONIC BUFFERED ACIDIC PEPTIDE AND PROTEIN FORMULATIONS

机译：两性离子缓冲酸肽和蛋白质制剂

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摘要

The present invention provides glycine buffered pharmaceutical compositions suitable for nasal administration and methods for nasal delivery of such compositions. The pharmaceutical compositions described herein include a therapeutically active peptide and/or protein admixed with an aqueous solution buffered with glycine and having a pH in the ranging from about 3.0 to 4.5. The compositions are formulated to maintain stability of the peptide for an extended period of time, but do not significantly change the normal pH of nasal mucosal secretions avoiding irritation and burning sensation in the nose upon administration.

机译：本发明提供了适合于鼻腔给药的甘氨酸缓冲的药物组合物以及这种组合物的鼻腔输送方法。本文所述的药物组合物包括与具有甘氨酸缓冲的水溶液混合的治疗活性肽和/或蛋白质，所述水溶液的pH在约3.0至4.5的范围内。配制该组合物以在较长的时间段内维持肽的稳定性，但是不会显着改变鼻粘膜分泌物的正常pH，从而避免了给药后鼻腔的刺激和烧灼感。

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公开/公告号US2010203014A1

专利类型
公开/公告日2010-08-12

原文格式PDF
申请/专利权人 EDWARD T. MAGGIO;
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申请/专利号US20100699776
发明设计人 EDWARD T. MAGGIO;
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申请日2010-02-03
分类号A61K38/21;A61K38/02;A61K38/08;A61K38/26;A61K38/23;A61K38/28;A61K38/22;A61K38/27;A61P3/10;
国家 US
入库时间 2022-08-21 18:56:33

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