首页> 外国专利> Novel proteins derived from mammals that negatively regulate cell surface expression of antigen presentation-related molecules such as B7-2 molecules or MHC class II molecules and use thereof

Novel proteins derived from mammals that negatively regulate cell surface expression of antigen presentation-related molecules such as B7-2 molecules or MHC class II molecules and use thereof

机译：源自哺乳动物的负性调节抗原呈递相关分子（例如B7-2分子或MHC II类分子）的细胞表面表达的新型蛋白质及其用途

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摘要

Human c-MIR cloned presently is a novel protein originating in a mammal such as a human homolog having an immune suppression function which is a molecule being similar in function to viral proteins, for example, K3 and K5 proteins of Kaposi's sarcoma-associated herpes virus. By analyzing the functions, it is observed that c-MIR has an immune suppression effect of inhibiting the expression of B7-2 molecule and MHC class II molecule, which are antigen presentation-associated molecules, on the cell surface. Because of having this immune suppression effect, c-MIR is considered as being a factor controlling the expression of an antigen presentation-associated molecule in a human immune system and, therefore, expected as usable in developing a new immune suppression method, inhibiting rejections in cell and organ transplantation, treating autoimmune diseases, developing new drugs and so on and thus highly useful in medicine and industries.

机译：目前克隆的人c-MIR是一种新的蛋白质，其起源于哺乳动物，例如具有免疫抑制功能的人同源物，该分子的功能与病毒蛋白类似，例如卡波西氏肉瘤相关疱疹病毒的K3和K5蛋白。。通过分析功能，观察到c-MIR具有抑制细胞表面上与抗原呈递相关的分子B7-2分子和MHC II类分子的表达的免疫抑制作用。由于具有这种免疫抑制作用，因此c-MIR被认为是控制人类免疫系统中与抗原呈递相关分子表达的因子，因此有望用于开发新的免疫抑制方法，从而抑制免疫系统中的排斥反应。细胞和器官移植，治疗自身免疫性疾病，开发新药等，因此在医学和工业中非常有用。

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公开/公告号JP4515266B2

专利类型
公开/公告日2010-07-28

原文格式PDF
申请/专利权人財団法人新産業創造研究機構;
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申请/专利号JP20040564468
发明设计人石戸聡;
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申请日2003-09-24
分类号C12N15/09;C12N9;C07K14/47;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;A61K31/7088;A61K48;A61K38;A61P37/06;C12Q1/25;G01N33/15;
国家 JP
入库时间 2022-08-21 18:59:00

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