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It is brief, in order the animal null which shows the diurnal rhythm rhythm of cyclic die or long

机译:简而言之,为了使动物表现出周期性的昼夜节律或长的昼夜节律

摘要

PROBLEM TO BE SOLVED: To provide a model animal exhibiting a short or long period circadian rhythm.;SOLUTION: The invention provides a non-human transgenic animal having extraneous PER2 gene. The transgenic animal exhibits a short or long-period circadian rhythm. Especially, a transgenic animal having a PER2 gene deleted in a nuclear transport sequence exhibits a long-period circadian rhythm. The invention further provides a method for preparing the transgenic animal and a method for screening a compound exerting an influence on sleep disorder by using the transgenic animal of the invention.;COPYRIGHT: (C)2006,JPO&NCIPI
机译:解决的问题:提供表现出短期或长期昼夜节律的模型动物。解决方案:本发明提供具有外源PER2基因的非人转基因动物。转基因动物表现出短或长的昼夜节律。特别地,在核转运序列中缺失PER2基因的转基因动物表现出长周期的昼夜节律。本发明还提供了使用本发明的转基因动物制备转基因动物的方法和筛选对睡眠障碍有影响的化合物的方法。版权所有:(C)2006,JPO&NCIPI

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