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It is brief, in order the animal null which shows the diurnal rhythm rhythm of cyclic die or long
It is brief, in order the animal null which shows the diurnal rhythm rhythm of cyclic die or long
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机译:简而言之,为了使动物表现出周期性的昼夜节律或长的昼夜节律
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摘要
PROBLEM TO BE SOLVED: To provide a model animal exhibiting a short or long period circadian rhythm.;SOLUTION: The invention provides a non-human transgenic animal having extraneous PER2 gene. The transgenic animal exhibits a short or long-period circadian rhythm. Especially, a transgenic animal having a PER2 gene deleted in a nuclear transport sequence exhibits a long-period circadian rhythm. The invention further provides a method for preparing the transgenic animal and a method for screening a compound exerting an influence on sleep disorder by using the transgenic animal of the invention.;COPYRIGHT: (C)2006,JPO&NCIPI
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