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NANOPARTICLE FOR DUAL MODAL IMAGING BY FLUORESCENCE AND MAGNETIC RESONANCE AND METHOD FOR PRODUCING THE SAME

机译：荧光和磁共振双模态成像的纳米粒子及其制备方法

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摘要

PPROBLEM TO BE SOLVED: To provide new nanoparticles having a positive contrast function for MRI and a method for producing the same, and to further provide new nanoparticles having two functions of near-infrared fluorescence and magnetic resonance imaging ability. PSOLUTION: The nanoparticles having a positive contrast agent function for MRI are obtained by using YAG nanoparticles having a garnet structure as a matrix and allowing gadolinium (Gd) to exist locally on surfaces thereof. A probe having two functions of near-infrared fluorescence and magnetic resonance imaging ability can be obtained by converting the YAG nanoparticles as a matrix to a solid solution doped with a rare earth metal such as YbSP3+/SP. PCOPYRIGHT: (C)2010,JPO&INPIT

机译：<要解决的问题：提供用于MRI的具有正对比功能的新型纳米颗粒及其制备方法，并进一步提供具有近红外荧光和磁共振成像能力的两种功能的新型纳米颗粒。

解决方案：通过使用具有石榴石结构的YAG纳米颗粒作为基质，并使g（Gd）局部存在于其表面上，从而获得具有MRI阳性造影剂功能的纳米颗粒。通过将作为基质的YAG纳米粒子转化为掺杂有Yb 3 + 等稀土金属的固溶体，可以获得具有近红外荧光和磁共振成像功能的两种探针。

版权：（C）2010，日本特许厅＆INPIT 展开▼

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公开/公告号JP2010037169A

专利类型
公开/公告日2010-02-18

原文格式PDF
申请/专利权人 KEIO GIJUKU;
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申请/专利号JP20080204063
发明设计人 ISOBE TETSUHIKO;ASAKURA AKIRA;SAKANE HIROSHI;MORITA MASASHI;INUBUSHI TOSHIRO;
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申请日2008-08-07
分类号C01F17;A61K49;B82B1;B82B3;A61B5/055;G01R33/28;C09K11/80;C09K11/08;
国家 JP
入库时间 2022-08-21 19:03:30

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