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ARE ANALYTISCHE SYSTEME

机译：是分析系统

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摘要

A liquid composition comprising a colloidal suspension of a biomolecule-binding matrix material (preferably nitrocellulose) dispersed in a liquid, with particles of the matrix material being of a defined particle size, and replicate copies of a biomolecule, e.g., protein or nucleic acid probes, which are distributed, preferably uniformly, throughout the colloidal suspension and are bound to the matrix material particles, is disclosed. The liquid composition of the invention can be used directly for sample analysis or preparation of biomolecules, or aliquots of the composition can be spotted onto a support to form a microporous matrix system or microarray for analysis or preparation of biomolecules. Compositions and microarrays according to the invention are useful in any type of analytical or preparative procedure relating to biomolecules. They are particularly useful, e.g., in methods for detecting a biomolecule analyte in a liquid sample, methods for determining the presence of a particular nucleic acid sequence within a liquid sample and methods for determining the presence of a drug candidate molecule in a liquid sample. The invention further comprises kits for practicing the various methods of the invention.

机译：液体组合物，其包含分散在液体中的生物分子结合基质材料（优选硝化纤维素）的胶体悬浮液，基质材料的颗粒具有确定的粒径，并复制生物分子的副本，例如蛋白质或核酸探针公开了优选地均匀地分布在整个胶体悬浮液中并结合到基质材料颗粒上的α，β。本发明的液体组合物可以直接用于样品分析或生物分子的制备，或者可以将组合物的等分试样点样到支持物上以形成用于分析或制备生物分子的微孔基质系统或微阵列。根据本发明的组合物和微阵列可用于与生物分子有关的任何类型的分析或制备过程中。它们特别有用，例如，用于检测液体样品中生物分子分析物的方法，确定液体样品中特定核酸序列的存在的方法以及确定液体样品中药物候选分子的存在的方法。本发明进一步包括用于实施本发明的各种方法的试剂盒。

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公开/公告号DE60137132D1

专利类型
公开/公告日2009-02-05

原文格式PDF
申请/专利权人 CENTER FOR BLOOD RESEARCH INC.;
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申请/专利号DE20016037132T
发明设计人 AUDEH ZUHEIR L.;FICI DOLORES A.;MCCORMICK WILLIAM;
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申请日2001-05-04
分类号G01N33/53;G01N33/543;B01J19;B01L3;C12M1;C12N15/09;C12Q1/68;C40B40/02;C40B40/06;C40B40/10;C40B50/06;G01N33/15;G01N33/50;G01N33/548;G01N33/566;
国家 DE
入库时间 2022-08-21 19:08:28

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