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首页> 外国专利> MEDICINES BASED ON OLIGO-NUCLEAR COORDINATION COMPOUNDS OF D-METALS, METHOD FOR THERAPEUTIC INFLUENCE ON THE PATIENT'S ORGANISM AND METHOD FOR IMPROVING THERAPEUTIC EFFICIENCY OF PHARMACOLOGY

MEDICINES BASED ON OLIGO-NUCLEAR COORDINATION COMPOUNDS OF D-METALS, METHOD FOR THERAPEUTIC INFLUENCE ON THE PATIENT'S ORGANISM AND METHOD FOR IMPROVING THERAPEUTIC EFFICIENCY OF PHARMACOLOGY

机译：基于D-金属的寡核配位化合物的药物，治疗对患者有机体的影响的方法以及提高药物治疗的功效的方法

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1. A medicine containing bi- or oligonuclear coordination compounds in an aqueous solution formed by the same or different d-metal atoms linked by one or more bridging groups and containing water molecules and / or in the inner sphere of each d-metal atom hydroxide groups, as well as labile ligands, which are easily replaced by sulfur atoms of thioamino acids or peptides, such as mono-, bi-, or higher-dentent organic molecules with bridging and non-bridging types of coordination to at ohms of d-metals. ! 2. The tool according to claim 1, containing in the composition of the inner sphere of each d-metal atom tightly bound ligands of any nature and dentality with bridge and non-bridge types of coordination to d-metal atoms,! 3. The tool according to claim 1, where the atoms of the d-metal (d-metals) in the coordination compound are interconnected by one or more bridging oxo and / or hydroxo groups. ! 4. The tool according to claim 1, where the labile ligands are oxygen-containing and / or nitrogen-containing and / or sulfur-containing organic molecules. ! 5. The tool according to claim 1, where the concentration of d-metal (d-metals) in the specified aqueous solution is less than 10-3 M.! 6. The tool according to claim 1, which also includes free molecules of the specified labile ligand, uncoordinated to d-metal atoms, where the molar ratio of the d-metal atom (d-metals): the labile ligand molecule is from 1: 1 to 1: 30000 . ! 7 The tool according to claim 1, where the coordination compound is obtained by the interaction of hydrohydroxocomplexes of d-metal (d-metals) and solutions of these labile ligands. ! 8. The tool according to any one of claims 1 to 7, having
机译：1.一种药物，该药物在通过相同或不同的d-金属原子通过一个或多个桥接基团连接而成的水溶液中包含双核或寡核配位化合物，并且在每个d-金属原子氢氧化物的内球中均含有水分子和/或基团以及不稳定的配体，它们很容易被硫代氨基酸或肽的硫原子取代，例如单，双或更高价的有机分子，其桥连和非桥连类型的配位基团为d-欧姆金属。 ！ 2.根据权利要求1所述的工具，其特征在于，在每个d-金属原子的内球的组成中紧密结合具有任何性质和牙齿性质的配体，所述配体具有与d-金属原子配位的桥型和非桥型。 3.根据权利要求1或2所述的工具，其特征在于，所述配位化合物中的d-金属原子通过一个或多个桥接的氧代和/或羟基基团相互连接。 ！ 4.根据权利要求1所述的工具，其中，所述不稳定的配体是含氧和/或含氮和/或含硫的有机分子。 ！ 5.根据权利要求1所述的工具，其中，所述特定水溶液中的d-金属的浓度小于10-3M。 6.根据权利要求1所述的工具，其还包括与d-金属原子不配位的所述特定的不稳定配体的自由分子，其中所述d-金属原子（d-金属）的摩尔比为：所述不稳定的配体分子为1。 ：1至1：30000 ！ 7.根据权利要求1所述的工具，其中，所述配位化合物是通过d-金属（d-金属）的氢氧配合物与这些不稳定的配体的溶液的相互作用而获得的。 ！ 8.根据权利要求1至7中任一项所述的工具，具有

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