首页> 外国专利> COMPOSITION COMPRISING 8-(TOSYLAMINO)QUINOLINE FOR THE PREVENTION OR TREATMENT OF INFLAMMATORY DISEASES, IMMUNE DISEASES OR TUMORS

COMPOSITION COMPRISING 8-(TOSYLAMINO)QUINOLINE FOR THE PREVENTION OR TREATMENT OF INFLAMMATORY DISEASES, IMMUNE DISEASES OR TUMORS

机译:包含8-(甲苯磺胺)喹啉的组合物,用于预防或治疗炎症性疾病,免疫性疾病或肿瘤

摘要

A composition comprising 8-(tosylamino)quinoline is provided to inhibit production of nitric oxide, growth of cancer cells and C6 glioma cell, production of PGE2(prostaglandin 2), and activity of IKK(I kappa B alpha kinase) and Src kinase, thereby preventing or treating inflammatory diseases, immune diseases or tumors. The composition for preventing or treating inflammatory diseases, immune diseases or tumors comprises 8-(tosylamino)quinoline or pharmaceutically acceptable salts thereof including an acid addition salt selected from hydrochloric acid, hydrobromic acid, phosphonic acid, sulfuric acid, tartaric acid, acetic acid, citric acid, malic acid, methanesulphonic acid and gluconic acid.
机译:提供了包含8-(甲苯磺酰基氨基)喹啉的组合物以抑制一氧化氮的产生,癌细胞和C6神经胶质瘤细胞的生长,PGE2(前列腺素2)的产生以及IKK(IκBα激酶)和Src激酶的活性,从而预防或治疗炎症性疾病,免疫性疾病或肿瘤。用于预防或治疗炎症性疾病,免疫性疾病或肿瘤的组合物包含8-(甲苯磺酰基氨基)喹啉或其药学上可接受的盐,包括选自盐酸,氢溴酸,膦酸,硫酸,酒石酸,乙酸的酸加成盐,柠檬酸,苹果酸,甲磺酸和葡萄糖酸。

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