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METHOD FOR REGULATION OF EXPRESSION OF LOW-DENSITY LIPOPROTEIN RECEPTOR, AND ENHANCER OF EXPRESSION OF LOW-DENSITY LIPOPROTEIN RECEPTOR

机译：调节低密度脂蛋白受体表达的方法及增强低脂脂蛋白受体表达的方法

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摘要

Disclosed are a novel method for regulating the expression of a low-density lipoprotein receptor (LDLR) and a novel enhancer of the expression of a LDLR, both of which can increase the expression level of a LDLR. The expression level of a LDLR can be increased by inhibiting the expression of a ZFP36 family. The inhibition of the expression of the ZFP36 family can utilize an expression vector which carries at least member selected from an antisense strand, double-stranded RNA and low-molecular-weight interfering RNA all for mRNA of the ZFP36 family or an expression vector which can express the at least one member.

机译：公开了调节低密度脂蛋白受体（LDLR）表达的新方法和LDLR表达的新型增强剂，两者均可以增加LDLR的表达水平。 LDLR的表达水平可以通过抑制ZFP36家族的表达而增加。对ZFP36家族的表达的抑制可以利用携带至少针对ZFP36家族的mRNA的选自反义链，双链RNA和低分子量干扰RNA中的成员的表达载体或可以表达至少一名成员。

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公开/公告号WO2009110324A1

专利类型
公开/公告日2009-09-11

原文格式PDF
申请/专利权人 NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY;NATSUME TORU;IEMURA SHUNICHIRO;
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申请/专利号WO2009JP52969
发明设计人 NATSUME TORU;IEMURA SHUNICHIRO;
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申请日2009-02-20
分类号A61K48;A61K31/7105;A61K31/713;A61K38;A61P3/04;A61P3/06;A61P3/10;A61P9/10;A61P9/12;A61P35;A61P43;C12N15/09;C12Q1/68;
国家 WO
入库时间 2022-08-21 19:17:02

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