首页> 外国专利> PHARMACEUTICAL FOR PROTECTION OF MOTOR NERVE IN PATIENT WITH AMYOTROPHIC LATERAL SCLEROSIS

PHARMACEUTICAL FOR PROTECTION OF MOTOR NERVE IN PATIENT WITH AMYOTROPHIC LATERAL SCLEROSIS

机译:肌萎缩侧索硬化症患者运动神经的药物制剂

摘要

The present invention relates to an agent for protecting a motor nerve of a patient with amyotrophic lateral sclerosis, which comprises a combination of (a) (2R)-2-propyloctanoic acid or a salt thereof and (b) a therapeutic agent for amyotrophic lateral sclerosis such as riluzole. An agent comprising a combination of (a) (2R)-2-propyloctanoic acid which is orally administered once a day in an amount per dose of about 1200 mg and (b) riluzole which is orally administered twice a day in an amount per dose of about 50 mg is useful for protecting a motor nerve in a patient(s) with amyotrophic lateral sclerosis. The agent can also suppress the respiratory disability associated with the progression of the disease condition and improve the survival rate of the patient(s).
机译:本发明涉及用于保护患有肌萎缩性侧索硬化症的患者的运动神经的药剂,其包含(a)(2R)-2-丙基辛酸或其盐与(b)肌萎缩性侧索硬化症的治疗剂的组合。硬化如利鲁唑。一种药物,包含(a)(2R)-2-丙基辛酸的组合,该组合以每天约1200 mg的剂量每天口服一次;和(b)利鲁唑,组合以每天每剂量的口服一天两次约50mg的剂量可用于保护肌萎缩性侧索硬化患者的运动神经。该药剂还可以抑制与疾病状况的发展有关的呼吸障碍,并提高患者的存活率。

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