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PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE -HYDROXYPHOSPHONIC ACIDS AND DERIVATIVES THEREOF, OPTICALLY ACTIVE ALUMINUM(SALALEN) COMPLEXES AND PROCESS FOR PRODUCTION OF THE COMPLEXES, AND PROCESS FOR PRODUCTION OF SALALEN LIGANDS
PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE -HYDROXYPHOSPHONIC ACIDS AND DERIVATIVES THEREOF, OPTICALLY ACTIVE ALUMINUM(SALALEN) COMPLEXES AND PROCESS FOR PRODUCTION OF THE COMPLEXES, AND PROCESS FOR PRODUCTION OF SALALEN LIGANDS
The present invention relates to a production method capable of producing an optically active α-hydroxyphosphonic acid and its derivatives with sufficiently high enantioselectivity not only for aromatic aldehydes but also for aliphatic aldehydes, and more specifically to a method of producing an optically active α-hydroxyphosphonic acid and its derivatives, characterized in that an optically active aluminum(salalen) complex represented by any one of the following formulae (I), (I'), (II) and (II'):[wherein R1s are each alkyl group or aryl group independently; R2s are each alkyl group or aryl group independently; R3s are each alkyl group or aryl group independently, and two R3s may bond with each other to form a ring; R4s are each hydrogen atom, halogen atom, alkyl group, alkoxy group, nitro group, or cyano group independently; R5 is alkyl group; and X1 is halogen atom, alkyl group, alkoxy group, acetoxy group or toluenesulfonyloxy group] is used as a catalyst to asymmetrically hydrophosphonylate an aldehyde with phosphonic acid or its derivatives.
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机译：光学活性α-羟基膦酸的制造方法技术领域本发明涉及不仅对芳香族醛而且对于脂肪族醛具有足够高的对映选择性的光学活性α-羟基膦酸及其衍生物的制造方法，更具体地说，涉及光学活性α-羟基膦酸的制造方法。酸及其衍生物，其特征在于由下式（I），（I'），（II）和（II'）中的任何一个表示的旋光铝（salalen）配合物：[其中R 1s各自独立地为烷基或芳基; R 2各自独立地为烷基或芳基; R 3分别独立地为烷基或芳基，两个R 3可以相互键合而形成环。 R 4各自独立地为氢原子，卤素原子，烷基，烷氧基，硝基或氰基; R5是烷基; [X1是卤素原子，烷基，烷氧基，乙酰氧基或甲苯磺酰氧基]用作催化剂，以使膦酸或其衍生物不对称地使醛进行羟基膦酰基化。
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