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Method to develop an organised microstructure within an implantable medical device

机译:在植入式医疗设备中开发有组织的微结构的方法

摘要

A method to facilitate the ability to engineer an organized microstructure within a monolithically homogeneous implantable biomaterial, particularly metallic alloys, is provided. By starting with an ultra-fine grained, equiaxed microstructure having an averaged linear grain size of less than 5 µm (5 microns), a functionally graded microstructure is developed by establishing a temperature gradient across the cross sectional dimension. In the case of a tubular product form, this dimension would be framed by the outer and inner surfaces. By ensuring one surface is held at a substantially lower temperature than the other surface a temperature gradient is developed. The present invention also provides an implantable medical device which includes an organized microstructure. In accordance with the present invention, the organized microstructure includes a first surface region having said ultra-fine grained, equiaxed microstructure and a second surface region comprising a recrystallized, coarser grained microstructure having an average linear grain size of greater than 25 µm (25 microns), wherein the first and second surface regions are separated by a transition region.
机译:提供了一种促进在单片均质的可植入生物材料,特别是金属合金中工程组织微结构的能力的方法。从平均线性晶粒尺寸小于5 µm(5微米)的超细晶粒等轴微结构开始,通过在整个横截面尺寸上建立温度梯度来开发功能梯度的微结构。在管状产品形式的情况下,该尺寸将由外表面和内表面限定。通过确保一个表面保持在比另一表面低得多的温度下,形成了温度梯度。本发明还提供了一种包括有组织的微结构的可植入医疗装置。根据本发明,有组织的微结构包括具有所述超细晶粒等轴微结构的第一表面区域和具有重结晶的,粗晶粒微结构的第二表面区域,所述平均平均线性晶粒尺寸大于25μm(25微米)。 ),其中第一和第二表面区域被过渡区域隔开。

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