首页> 外国专利> GENE EXPRESSION PROFILING IN PRIMARY OVARIAN SEROUS PAPILLARY TUMORS AND NORMAL OVARIAN EPITHELIUM

GENE EXPRESSION PROFILING IN PRIMARY OVARIAN SEROUS PAPILLARY TUMORS AND NORMAL OVARIAN EPITHELIUM

机译:基因表达在原发性卵巢浆液性乳腺肿瘤和正常卵巢上皮中的表达。

摘要

Gene expression profiling and hierarchal clustering analysis readily distinguish normal ovarian epithelial cells from primary ovarian serous papillary carcinomas. Laminin, tumor-associated calcium signal transducer 1 and 2 (TROP-1/Ep-CAM; TROP-2), claudin 3, claudin 4, ladinin 1, S100A2, SERPIN2 (PAI-2), CD24, lipocalin 2, osteopontin, kallikrein 6 (protease M), kallikrein 10, matriptase and stratifin were found among the most highly overexpressed genes in ovarian serous papillary carcinomas, whereas transforming growth factor beta receptor III, platelet-derived growth factor receptor alpha, SEMACAP3, ras homolog gene family, member I (ARHI), thrombospondin 2 and disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2) were significantly down-regulated. Therapeutic strategy targeting TROP-1/Ep-CAM by monoclonal chimeric/humanized antibodies may be beneficial in patients harboring chemotherapy-resistant ovarian serous papillary carcinomas.
机译:基因表达谱分析和层次聚类分析很容易将正常卵巢上皮细胞与原发性卵巢浆液性乳头状癌区分开。层粘连蛋白,肿瘤相关钙信号转导物1和2(TROP-1 / Ep-CAM; TROP-2),claudin 3,claudin 4,ladinin 1,S100A2,SERPIN2(PAI-2),CD24,lipocalin 2,骨桥蛋白,在卵巢浆液性乳头状癌中,激肽释放酶6(蛋白酶M),激肽释放酶10,matriptase和stratifin被发现是表达最高的基因,而转化生长因子β受体III,血小板衍生的生长因子受体α,SEMACAP3,ras同源基因家族,成员I(ARHI),血小板反应蛋白2和在卵巢癌2(Dab2 / DOC2)中差异表达的残疾2 /差异显着下调。单克隆嵌合/人源化抗体靶向TROP-1 / Ep-CAM的治疗策略可能对具有化疗耐药性卵巢浆液性乳头状癌的患者有益。

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