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Use of compounds capable of binding to glycoprotein gpIIb/IIIa for the prevention of restenosis
Use of compounds capable of binding to glycoprotein gpIIb/IIIa for the prevention of restenosis
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机译：能够与糖蛋白gpIIb / IIIa结合的化合物在预防再狭窄中的用途
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摘要
Platelet-specific, chimeric immunoglobulin and immunoglobulin fragments are described. The chimeric molecules are made up of a nonhuman antigen binding region and a human constant region. Preferred immunoglobulins are specific for glycoprotein IIb/IIIa receptor in its complexed form; they block ligand binding to the receptor and prevent platelet aggregation. The immunoglobulins can be used to reduce or prevent occlusion, reocclusion (e.g, abrupt closure), stenosis and/or restenosis. In addition, the immunoglobulins are useful in anti-thrombotic therapy when administered alone or in conjunction with thrombolytic agents, as well as in thrombus imaging.
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