首页> 外国专利> A METHOD OF TREATING HIV INFECTION IN ATAZANAVIR RESISTANT PATIENTS USING A COMBINATION OF ATAZANAVIR AND ANOTHER PROTEASE INHIBITOR

A METHOD OF TREATING HIV INFECTION IN ATAZANAVIR RESISTANT PATIENTS USING A COMBINATION OF ATAZANAVIR AND ANOTHER PROTEASE INHIBITOR

机译：阿扎那韦和另一种蛋白酶抑制剂联合治疗抗阿扎那病毒患者的艾滋病毒感染的方法

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摘要

A method of treating HIV infection in a human patient wherein the infecting HIV strain has become resistant to atazanavir, the method comprising administration of a therapeutically effective amount of a combination of atazanavir or a pharmaceutically acceptable salt thereof, and at least one other HIV protease inhibitor. A method for enhancing the effectiveness of a second HIV protease inhibitor in treating HIV infection in a human patient whose HIV strain has become resistant to atazanavir or a pharmaceutically acceptable salt thereof, comprising administering to said human patient an amount of atazanavir or a pharmaceutically acceptable salt thereof effective in maintaining the resistant strain, in combination with the second HIV protease inhibitor. The resistance to atazanavir in the human is manifested by the existence of the signature mutation consisting of I50L mutation in the HIV protease.

机译：一种在人类患者中治疗HIV感染的方法，其中所述感染的HIV株已变得对阿扎那韦具有抗性，所述方法包括给予治疗有效量的阿扎那韦或其药学上可接受的盐和至少一种其他HIV蛋白酶抑制剂的组合。一种增强第二种HIV蛋白酶抑制剂在HIV株已对阿扎那韦或其药学上可接受的盐具有抗药性的人类患者中治疗HIV感染的有效性的方法，包括向所述人类患者施用一定量的阿扎那韦或其药学上可接受的盐与第二HIV蛋白酶抑制剂联合使用可有效维持抗性菌株。人类对阿扎那韦的抗药性由HIV蛋白酶中由I50L突变组成的特征突变的存在来证明。

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公开/公告号EP1696918A4

专利类型
公开/公告日2008-12-31

原文格式PDF
申请/专利权人 BRISTOL-MYERS SQUIBB COMPANY;
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申请/专利号EP20040814181
发明设计人 COLONNO RICHARD J.;FRIBORG JACQUES JR.;ROSE RONALD E.;
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申请日2004-12-14
分类号A61K31/4418;A61K;A61K31/341;A61K31/426;A61K31/435;A61K31/44;A61K31/4709;A61K31/496;A61K31/551;A61K31/7056;A61P31/20;
国家 EP
入库时间 2022-08-21 19:20:19

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