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FUNCTIONAL ASSAY TO INVESTIGATE UNCLASSIFIED SEQUENCE VARIANTS OF MISMATCH REPAIR GENES
FUNCTIONAL ASSAY TO INVESTIGATE UNCLASSIFIED SEQUENCE VARIANTS OF MISMATCH REPAIR GENES
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机译:进行功能不全的调查,以对错误修复基因的未分类序列变体进行调查
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摘要
The present invention relates to methods of conducting in vitro functional mismatch repair assays, in order to detect whether a mismatch repair gene from a test subject, is incapable of functioning, when the mismatch repair gene comprises a mutation. Such assays are of use in detecting whether or not a subject may be predisposed or have an increased risk of developing cancer, such as hereditary nonpolyposis colorectal cancer (HNPCC).
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