TREATMENT OF GLOMERULAR BASEMENT MEMBRANE DISEASE INVOLVING MATRIX METALLOPROTEINASE-12
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机译:基质金属蛋白酶12对肾小球基底膜疾病的治疗
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摘要
Methods for treating glomerular basement membrane disease such as Alport syndrome involving matrix metalloproteinase-12 are disclosed. Treatment may be affected, for example, by administering matrix metal] oproteinase-12 inhbitors, by administering CCR2 receptor inhibitors, or by administering MCP-1 inhibitors. Matrix metalloproteinase formation is affected by the CCR2 receptor, which is stimulated by the MCP-1 chemokine.
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