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MODEL ANIMAL WITH ONSET OF COLLAGEN-INDUCED ARTHRITIS
MODEL ANIMAL WITH ONSET OF COLLAGEN-INDUCED ARTHRITIS
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机译：胶原诱导性关节炎发作的动物模型
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摘要
The present invention provides a model animal withfavorite onset of rheumatoid arthritis wherein the severity ofarthritis reaches the maximum level and its onset ratio is ahundred percent, and a screening method of a remedy forrheumatoid arthritis by using the model animal. A mouse whosefunction of immunoglobulin Fc.gamma. receptor IIB gene is deficienton its chromosome and a wild-type collagen-inducedarthritis-susceptible DBA/1J mouse are backcrossed six timesor more, and a model mouse with favorite onset of rheumatoidarthritis is constructed. This model mouse with favorite onsetof rheumatoid arthritis is immunized with bovine joint-origintype II collagen to develop collagen-induced arthritis.
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