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PYRADAZINE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST INTERLEUKIN-1.BETA. PRODUCTION

机译：吡嗪衍生物对白细胞介素-1.BETA具有抑制活性。生产

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摘要

Pyridazine derivatives represented by general formula (1) or salts thereof,wherein R1 represents lower alkoxy, lower alkylthio orhalogeno; R2 represents H, lower alkoxy, lower alkylthio or halogeno; R3represents OH, CN, halogeno, lower cycloalkyl, lower alkyl orlower alkenyl optionally substituted by an optionally substituted aromaticgroup or optionally substituted carbamoyl; R4 represents COOH,lower alkoxycarbonyl, optionally substituted carbamoyl, optionally substitutedamino or optionally substituted ureido; and the broken linemeans a single bond or a double bond between the carbon atoms at the 4- and 5-positions. Because of having an excellent effect of regulatinginterleukin-1.beta. production, these compounds are useful aspreventives/remedies for immunologic diseases, inflammatory diseases, ischemicdiseases, etc.

机译：通式（1）表示的哒嗪衍生物或其盐，其中R1代表低级烷氧基，低级烷硫基或卤素R2代表H，低级烷氧基，低级烷硫基或卤代基; R3代表OH，CN，卤代，低级环烷基，低级烷基或任选被任选取代的芳族取代的低级烯基基团或任选取代的氨基甲酰基; R4代表COOH，低级烷氧羰基，任选取代的氨基甲酰基，任选取代氨基或任选取代的脲基;和虚线表示在4-和5-碳原子之间的单键或双键职位。由于具有极好的调节作用白介素-1生产中，这些化合物可用作免疫疾病，炎性疾病，缺血性疾病的预防/治疗疾病等

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公开/公告号CA2321254C

专利类型
公开/公告日2008-12-09

原文格式PDF
申请/专利权人 KOWA CO. LTD.;
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申请/专利号CA19992321254
发明设计人 OHKUCHI MASAO;KYOTANI YOSHINORI;SHIGYO HIROMICHI;YOSHIZAKI HIDEO;KOSHI TOMOYUKI;KITAMURA TAKAHIRO;MATSUDA TAKAYUKI;ODA SOICHI;HABATA YURIKO;KOTAKI KYOKO;
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申请日1999-02-26
分类号C07D237/22;A61K31/50;C07D237/04;
国家 CA
入库时间 2022-08-21 19:23:36

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