首页>
外国专利>
USE OF CREATINE OR CREATINE ANALOGS FOR THE TREATMENT OF DISEASES OF THE NERVOUS SYSTEM
USE OF CREATINE OR CREATINE ANALOGS FOR THE TREATMENT OF DISEASES OF THE NERVOUS SYSTEM
展开▼
机译：肌酐或肌酐类似物用于神经系统疾病的治疗
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to the use of creatine compounds includingcreatine, creatine phosphate or analogs of creatine, such ascyclocreatine, for treating diseases of the nervous system. Creatine compoundscan be used as therapeutically effective agents against avariety of diseases of the nervous system such as diabetic and toxicneuropathies, peripheral nervous system diseases, Alzheimer disease,Parkinson's disease, stroke, Huntington's disease, motor neuron disease,traumatic nerve injury, multiple sclerosis, dysmyelination anddemyelination disorders, and mitochondrial diseases. The Creatine compoundswhich can be used in the present method include: (1)creatine, creatine phosphate and analogs of these compounds which can act assubstrates or substrate analogs for creatine kinase; (2)bisubstrate inhibitors of creatine kinase comprising covalently linkedstructural analogs of adenosine triphosphate (ATP) and creatine; (3)creatine analogs which can act as reversible or irreversible inhibitors ofcreatine kinase; and (4) N-phosphorocreatine analogs bearingnon-transferable moieties which mimic the N-phosphoryl group.
展开▼
