首页> 外国专利> FORMS OF MULTI-PAPER MEDICINES CONTAINING ACTIVE PRINCIPLES, THAT INCLUDE A NEUTRAL NUCLEUS AND AN INTERIOR AND EXTERIOR COATING OF METOLRILATE COPOLIMEROS AND MONOMEROS.

FORMS OF MULTI-PAPER MEDICINES CONTAINING ACTIVE PRINCIPLES, THAT INCLUDE A NEUTRAL NUCLEUS AND AN INTERIOR AND EXTERIOR COATING OF METOLRILATE COPOLIMEROS AND MONOMEROS.

机译:包含活性成分的多种药物的形式,包括中性核以及间苯二酚的结肠炎和莫诺莫司的内外涂层。

摘要

Multilayer drug form, formed by a) a neutral core, b) an inner coating based on a methacrylate copolymer c) an outer coating based on a copolymer, which is constituted by 40 to 95% by weight of C1-alkyl esters C4 of the radical polymerized acrylic or methacrylic acid and 5 to 60% by weight of (meth) acrylate monomers with an anionic group in the alkyl moiety characterized in that the inner lining is essentially composed of a methacrylate copolymer, which is formed at least at 90% by weight by (meth) acrylate monomers with neutral moieties, it exhibits a minimum film-forming temperature according to DIN 53787 of 30 ° C maximum and contains the pharmaceutical active ingredient in combination.
机译:多层药物形式,由a)中性核形成,b)基于甲基丙烯酸酯共聚物的内涂层c)基于共聚物的外涂层,其由40-95%重量的C1-烷基酯C4组成自由基聚合的丙烯酸或甲基丙烯酸和5至60%(重量)在烷基部分带有阴离子基团的(甲基)丙烯酸酯单体,其特征在于内衬主要由甲基丙烯酸酯共聚物组成,该共聚物至少占90%。通过具有中性部分的(甲基)丙烯酸酯单体重量,其根据DIN 53787表现出的最低成膜温度最高为30℃,并且包含药物活性成分的组合。

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