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RAT MODEL OF DIABETES NEPHROPATHY

机译:糖尿病肾病大鼠模型

摘要

A rat model of diabetic nephropathy is disclosed. In another embodiment of the invention, a method of evaluating a test compound's effect of diabetic nephropathy is disclosed. In one embodiment, this method comprises the steps of (a) exposing the test compound to the rat of claim 1, wherein the rat would develop progressive proteinuria and glomerulosclerosis leading to diabetic nephropathy in the absence of the test compound, and (b) comparing the rat's development of diabetic nephropathy with a control T2DN mimic rat that has not been exposed to the test compound.
机译:公开了糖尿病性肾病的大鼠模型。在本发明的另一个实施方案中,公开了评估测试化合物对糖尿病性肾病的作用的方法。在一个实施方案中,该方法包括以下步骤:(a)在权利要求1的大鼠中暴露测试化合物,其中在不存在测试化合物的情况下,大鼠会发展为进行性蛋白尿和肾小球硬化,从而导致糖尿病性肾病,和(b)比较尚未暴露于测试化合物的对照T2DN模仿大鼠在糖尿病性肾病中的发展。

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