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ANALYSIS AND TYPING OF MONOCLONAL PROTEINS BY MEANS OF CAPILLARY ELECTROPHORESIS AND IMMUNO DISTRIBUTION
ANALYSIS AND TYPING OF MONOCLONAL PROTEINS BY MEANS OF CAPILLARY ELECTROPHORESIS AND IMMUNO DISTRIBUTION
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机译:毛细血管电泳和免疫分布的方法对单核蛋白的分析和分型
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摘要
Analyzing a biological sample by capillary electrophoresis consists of initiating negatively charged modified antibodies so that they migrate to a zone outside the migration zone of the sample's proteins when they are separated during electrophoresis, with the antibodies having an antigen specificity for a predetermined target protein. The constituents of a first aliquot part of the biological sample are separated by capillary electrophoresis in the presence of the negatively charged antibodies capable of forming an antigen-antibody complex with a protein that might be present in the sample, and the separated constituents are detected. The electrophoretic profile obtained in the first stage is compared with the profile of the constituents of another aliquot part of the same sample separated by capillary electrophoresis in the absence of the modified antibodies.
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