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METHOD FOR SCREENING POTENTIAL COMPOUNDS FOR DETECTING AN ANTI-TUMOR MEDICAMENT

机译:一种用于检测抗肿瘤药物的潜在化合物的筛选方法

摘要

Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3/ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3/ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3/ITD functions as an index.
机译:对在各种血液癌中发​​现的FLT3 / ITD频率的调查显示,尤其是在急性粒细胞白血病中,该频率很高。对FLT3 / ITD在血细胞系中的作用的研究表明,FLT3 / ITD中的酪氨酸残基在这些细胞系中组成性地被磷酸化,引入FLT3 / ITD的血细胞显示出IL-3独立的增殖。此外,发现引入了FLT3 / ITD的血细胞能够形成肿瘤并抑制细胞分化。发明人发现,可以通过将这些FLT3 / ITD功能的抑制作用用作指标来筛选针对肿瘤的药物化合物。

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