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Producing antibodies directed against a surface antigen of a drug-resistant form of a native tumor comprises selecting antibodies that recognize the resistant tumor but not the native tumor
Producing antibodies directed against a surface antigen of a drug-resistant form of a native tumor comprises selecting antibodies that recognize the resistant tumor but not the native tumor
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机译：针对天然肿瘤的药物抗性形式的表面抗原的产生抗体包括选择识别抗性肿瘤但不能识别天然肿瘤的抗体
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摘要
Producing antibodies directed against a surface antigen of a drug-resistant form of a native tumor comprises immunizing animals with a cell homogenate, suspension or lysate derived from the resistant tumor and selecting antibodies that recognize the resistant tumor but not the native tumor. Independent claims are also included for: (1) a monoclonal antibody (I) produced as above; (2) a murine hybridoma capable of secreting (I); (3) nucleic acid (II) coding for (I) or hybridizing with a sequence coding for a complementarity-determining region, light chain or heavy chain of (I); (4) vector containing (II); (5) host cell containing the vector; (6) nonhuman transgenic animal comprising a cell transformed with the vector; (7) producing (I) by culturing a cell as above; (8) identifying therapeutic or diagnostic targets involved in drug resistance by producing an antibody as above and identifying the protein recognized by the antibody. ACTIVITY : Cytostatic. MECHANISM OF ACTION : Passive immunization.
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