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PHARMACOGENETIC MARKER OF HUMAN TRANSFORMING GROWTH FACTOR BETA1 (TGFß1) FOR PREDICTING PREDISPODITION TO IMMUNOLOGICAL DISORDERS
PHARMACOGENETIC MARKER OF HUMAN TRANSFORMING GROWTH FACTOR BETA1 (TGFß1) FOR PREDICTING PREDISPODITION TO IMMUNOLOGICAL DISORDERS
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机译:人体转化生长因子BETA1(TGFß1)的药物遗传标记,用于预测免疫性疾病的分布
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摘要
Asthma is a chronic lung disorder characterized by inflammation as a result of complex interactions between cells, their mediators and tissues in the airways. Various genetic and environmental factors are known to affect the disease process. Of the genetic factors, human Transforming Growth Factor Betal (TGFß1) is an important candidate gene for causation of susceptibility and/or pathogenesis. TGFß1 plays a dual role. On one hand, where it suppresses inflammation and decreases airway hyper reactivity in lungs, it also has a pro-inflammatory role where it is one of the mediators involved in subepithelial fibrosis, which is a fundamental feature of the remodeled airway in chronic asthmatics. The present invention relates to allelic variants of the human Transforming Growth Factor Betal (TGFß1)gene and provides primers and methods suitable for the detection of these allelic variants for applications such as molecular diagnosis, prediction of an individual's disease susceptibility, and/or the genetic analysis of the (TGFß1) gene in a population. Specifically, the invention provides a method for detection of predisposition to atopic disorders /other immunological disorders such as, autoimmune disorders, inflammatory disorders (especially in concern with liver), cancer, multiple sclerosis, fibrosis, tuberculosis, sarcoidosis, hypertension and disorders developing due to hypertension, diabetes and disorders developing due to diabetes, alcohol abuse, anxiety, asthma, chronic obstructive pulmonary disease (COPD), cholecystectomy, degenerative joint disease (DJD), seizure disorder, arthritis, etc. where human Transforming Growth Factor Betal(TGFß1)plays an important role.
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