首页> 外国专利> PHARMACOGENETIC MARKER OF HUMAN TRANSFORMING GROWTH FACTOR BETA1 (TGFß1) FOR PREDICTING PREDISPODITION TO IMMUNOLOGICAL DISORDERS

PHARMACOGENETIC MARKER OF HUMAN TRANSFORMING GROWTH FACTOR BETA1 (TGFß1) FOR PREDICTING PREDISPODITION TO IMMUNOLOGICAL DISORDERS

机译:人体转化生长因子BETA1(TGFß1)的药物遗传标记,用于预测免疫性疾病的分布

摘要

Asthma is a chronic lung disorder characterized by inflammation as a result of complex interactions between cells, their mediators and tissues in the airways. Various genetic and environmental factors are known to affect the disease process. Of the genetic factors, human Transforming Growth Factor Betal (TGFß1) is an important candidate gene for causation of susceptibility and/or pathogenesis. TGFß1 plays a dual role. On one hand, where it suppresses inflammation and decreases airway hyper reactivity in lungs, it also has a pro-inflammatory role where it is one of the mediators involved in subepithelial fibrosis, which is a fundamental feature of the remodeled airway in chronic asthmatics. The present invention relates to allelic variants of the human Transforming Growth Factor Betal (TGFß1)gene and provides primers and methods suitable for the detection of these allelic variants for applications such as molecular diagnosis, prediction of an individual's disease susceptibility, and/or the genetic analysis of the (TGFß1) gene in a population. Specifically, the invention provides a method for detection of predisposition to atopic disorders /other immunological disorders such as, autoimmune disorders, inflammatory disorders (especially in concern with liver), cancer, multiple sclerosis, fibrosis, tuberculosis, sarcoidosis, hypertension and disorders developing due to hypertension, diabetes and disorders developing due to diabetes, alcohol abuse, anxiety, asthma, chronic obstructive pulmonary disease (COPD), cholecystectomy, degenerative joint disease (DJD), seizure disorder, arthritis, etc. where human Transforming Growth Factor Betal(TGFß1)plays an important role.
机译:哮喘是一种慢性肺部疾病,其特征在于炎症是由于细胞,其介质和气道组织之间复杂的相互作用导致的。已知各种遗传和环境因素都会影响疾病进程。在遗传因素中,人类转化生长因子Betal(TGFß1)是引起易感性和/或发病机理的重要候选基因。 TGFß1扮演双重角色。一方面,它在抑制炎症并降低肺部气道高反应性的同时,还具有促炎作用,它是参与上皮下纤维化的介质之一,这是慢性哮喘患者气道重塑的基本特征。本发明涉及人类转化生长因子Betal(TGFβ1)基因的等位基因变体,并提供适于检测这些等位基因变体的引物和方法,用于分子诊断,预测个体疾病易感性和/或遗传学等应用。 (TGFß1)基因的克隆分析。具体地说,本发明提供了一种检测易感性疾病/其他免疫疾病如自身免疫疾病,炎性疾病(特别是与肝脏有关),癌症,多发性硬化症,纤维化,结核,结节病,高血压和因疾病发展的疾病的易感性的方法。患有高血压,糖尿病和由于糖尿病,酗酒,焦虑,哮喘,慢性阻塞性肺疾病(COPD),胆囊切除术,退行性关节疾病(DJD),癫痫发作,关节炎等导致的疾病,其中人类转化生长因子Betal(TGFß1 )扮演重要角色。

著录项

  • 公开/公告号IN233755B

    专利类型

  • 公开/公告日2009-05-15

    原文格式PDF

  • 申请/专利权人

    申请/专利号IN1037/DEL/2004

  • 申请日2004-06-04

  • 分类号C12N15/00;

  • 国家 IN

  • 入库时间 2022-08-21 19:26:41

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