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Method analu00ectico for determination of amitriptyline in pharmaceutical formulations by exploring the concept of clean chemistry going on
Method analu00ectico for determination of amitriptyline in pharmaceutical formulations by exploring the concept of clean chemistry going on
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机译：通过探索清洁化学的概念来分析药物制剂中阿米替林的方法
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摘要
Method analu00ectico for determination of amitriptyline in pharmaceutical formulations by exploring the concept of clean chemistry going on. The present invention relates to the development of an analytical method for the determination of amitriptyline in pharmaceutical formulation using flow injection analysis system.The method is based on the interaction of amitriptyline with sodium lauryl sulfate in acid medium, resulting in the formation of an ion pair detected turbidimetricamente. The calibration curve was linear range of 2.0 x 10 ^ - 3 ^ to 3.2 x 10 ^ - 3 ^ mol L ^ - 1 ^ (ABS = - 27417 + 01538 (amitriptyline) (r = 099991) and a detection limit of 1.8 x 10 ^ - 3 ^ mol L ^ - 1 was obtained:.The accuracy of the method, assessed from the relative standard deviation (n = 10) was 2.40 and 1.94% for concentrations of amitriptyline 2.0 x 10 ^ - 3 ^ and 3.2 x 10 ^ - 3 ^ MOI L ^ - 1 ^. The frequency analytical method was 60 samples per hour. To evaluate the applicability of the method four samples were analysed as a, B, C and D.The results obtained were compared with a reference method published in the literature. According to the results and by applying the t test with a confidence level of 95%, it was found that the proposed method shows no significant statistic difference compared to the reference method, thus confirming the accuracy for the samples analyzed.The invention presented here has several advantages including simplicity, low consumption of samples and reagents due to mechanization of the analysis, low cost, and high frequency analysis can be successfully applied in quality control laboratories for monitoring Amitriptyline in pharmaceutical formulations.Also, it should be noted that the invention falls within the concept of chemical clean, because it is the employee surfactant sodium lauryl sulfate as a reagent, unlike the usual methods which make use of organic solvents.
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机译：通过探索清洁化学的概念，用于分析药物制剂中阿米替林的分析方法。本发明涉及使用流动注射分析系统测定药物制剂中阿米替林的分析方法的开发，该方法基于阿米替林与酸性介质中月桂基硫酸钠的相互作用，导致形成离子对检测到浊度。校准曲线的线性范围为2.0 x 10 ^-3 ^至3.2 x 10 ^-3 ^ mol L ^-1 ^（ABS =-27417 + 01538（阿米替林）（r = 099991）和检测限为1.8 x得到10 ^-3 ^ mol L ^-1。根据阿米替林2.0 x 10 ^-3 ^和3.2 x的阿米替林浓度，从相对标准偏差（n = 10）评估方法的准确性为2.40和1.94％。 10 ^-3 ^ MOI L ^-1 ^。频率分析方法为每小时60个样本。为了评估该方法的适用性，分析了四个样本的a，B，C和D.将所得结果与参考值进行比较根据结果并通过以95％的置信度进行t检验，发现该方法与参考方法相比在统计上没有显着差异，从而确认了所分析样品的准确性此处提出的发明具有几个优点，包括简单，样品消耗少和试剂由于分析的机械化，低成本和高频分析可以成功地用于质量控制实验室，以监测药物制剂中的阿米替林。此外，应该指出的是，本发明属于化学清洁的概念，因为员工使用的表面活性剂月桂基硫酸钠作为试剂，这与使用有机溶剂的常规方法不同。
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