首页> 外国专利> Method for Detecting the presenc of calicheamicin component of calicheamicin conjugate carrier in a Fluid Sample and Kit for determining the concentration of calicheamicin present in a Sample

Method for Detecting the presenc of calicheamicin component of calicheamicin conjugate carrier in a Fluid Sample and Kit for determining the concentration of calicheamicin present in a Sample

机译:检测液体样品中加利车霉素共轭载体加利车霉素成分的方法和测定样品中加利车霉素浓度的试剂盒

摘要

A method for Detecting the presence of a component of calicheamicin conjugated to calicheamicin carrier in a Sample Run, where the calicheamicin binds covalently to the bearer. Breaks the link between the calicheamicin and Carrier, it releases the portion of calicheamicin and detected the calicheamicin conjugate Carrier.And a Kit for determining the concentration of calicheamicin present in a Sample, with instructions to break the disulfide bond between the calicheamicin Antibody and an Anti Oxidant and reducing Agent.Claim 2: the method of claim 1, wherein the calicheamicin conjugate released the carrier calicheamicin is detected by mass spectrometry.
机译:一种在样品运行中检测与加利车霉素载体缀合的加利车霉素成分的方法,其中加利车霉素与载体共价结合。断开加利车霉素和载体之间的联系,释放出加利车霉素的一部分并检测出加利车霉素结合物载体;以及一套用于测定样品中加利车霉素浓度的试剂盒,其中包括打破加利车霉素抗体与抗人体内二硫键的说明氧化剂和还原剂。权利要求2:权利要求1的方法,其中通过质谱法检测释放载体卡奇霉素的卡奇霉素结合物。

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