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Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)

机译:海因和相关杂环作为基质金属蛋白酶和/或TNF-α转换酶(TACE)的抑制剂

摘要

The present application describes novel hydantoin derivatives of formula (I):; embedded image or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R5, R6, R7, R11, and n are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), aggrecanase, or a combination thereof.
机译:本申请描述了式(I)的新型乙内酰脲衍生物: “嵌入式图像” 或其药学上可接受的盐或前药形式,其中A,B,R 1 ,R 2 ,R 3 ,R 4 < / Sup>,R 5 ,R 6 ,R 7 ,R 11 和n在本说明书,其可用作基质金属蛋白酶(MMP),TNF-α转化酶(TACE),软骨聚集蛋白聚糖酶或其组合的抑制剂。

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