首页>
外国专利>
Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
展开▼
机译:对映选择性生物转化制备蛋白酪氨酸激酶抑制剂中间体
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.
展开▼