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Use of an epitope of vascular endothelial growth factor receptor KDR/Flk-1

机译:血管内皮生长因子受体KDR / Flk-1的表位的使用

摘要

The present invention relates to the use of the epitope which comprises the tyrosine at position 1214 in the amino acid sequence of the vascular endothelial growth factor receptor, KDR/Flk-1, as a marker in the measurement of a change in the activation state of the KDR/Flk-1 receptor and to probes, such as antibodies, which recognize said epitope. The invention also relates to the use of KDR/Flk-1 epitope Y1214 as a marker in the detection of and/or measurement of the level of the KDR/Flk-1 receptor and to assays which utilize the use of the Y1214 epitope and to compounds derived from said assays.
机译:本发明涉及在血管内皮生长因子受体KDR / Flk-1的氨基酸序列中包含在1214位酪氨酸的表位作为标记物在测量其激活状态变化中的用途。 KDR / Flk-1受体和识别所述表位的探针(例如抗体)。本发明还涉及KDR / Flk-1表位Y1214作为标记物在检测和/或测量KDR / Flk-1受体水平中的用途,并且涉及利用Y1214表位的测定方法,以及来自所述测定的化合物。

著录项

  • 公开/公告号US7541027B2

    专利类型

  • 公开/公告日2009-06-02

    原文格式PDF

  • 申请/专利权人 SUE ANN CARTLIDGE;

    申请/专利号US20040507164

  • 发明设计人 SUE ANN CARTLIDGE;

    申请日2003-03-11

  • 分类号A61K39/395;A61K38/04;G01N33/53;C07K4/12;C07K16/28;

  • 国家 US

  • 入库时间 2022-08-21 19:29:36

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