首页>
外国专利>
Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof
Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof
展开▼
机译：具有单斜空间基团对称性c2的人β分泌酶的晶体及其结晶方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides a crystal of human beta-secretase (BACE) having monoclinic space group symmetry C2, in a representative example, comprising a unit cell having dimensions of a, b, and c, wherein a is about 53 Å to about 103 Å, b is about 85 Å to about 125 Å, c is about 40 Å to about 60 Å, and α=γ=90°, and β is about 85° to about 105°, and in a preferred example, comprising unit cell dimensions as follows: a is 73.1 Å, b is 105.1 Å, c is 50.5 Å, and α=γ=90°, and β is 94.8, wherein the Matthews coefficient of said crystal is 2.1 Å/Da with 42% solvent, and wherein said crystal diffracts to 1.7 Å resolution.
展开▼
