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METHODS AND COMPOSITIONS FOR ENHANCING DEVELOPMENTAL POTENTIAL OF OOCYTES AND PREIMPLANTATION EMBRYOS

机译:增强卵母细胞和胚胎植入前胚胎发育潜能的方法和成分

摘要

The invention relates to compositions and methods for enhancing the developmental potential of oocytes or preimplantation embryos by modulating mitochondrial-associated proteins and/or genomic integrity modifier proteins in the oocytes or preimplantation embryos. In one aspect of the invention, the levels of one or more mitochondrial-associated proteins and/or genomic integrity modifier proteins are increased, in particular by introducing the mitochondrial-associated proteins and/or genomic integrity modifier proteins into the oocytes or preimplantation embryos. Oocytes may be fertilized to obtain a zygote with increased levels of one or more mitochondrial-associated proteins and/or genomic integrity modifier proteins. The methods and compositions may be used to improve in vitro fertilization and embryo transfer methods, and nuclear transfer techniques.
机译:本发明涉及通过调节卵母细胞或植入前胚胎中的线粒体相关蛋白和/或基因组完整性修饰蛋白来增强卵母细胞或植入前胚胎的发育潜力的组合物和方法。在本发明的一方面,特别是通过将线粒体相关蛋白和/或基因组完整性修饰剂蛋白引入卵母细胞或植入前胚胎中来增加一种或多种线粒体相关蛋白和/或基因组完整性修饰剂蛋白的水平。可以使卵母细胞受精以获得具有增加的一种或多种线粒体相关蛋白和/或基因组完整性修饰剂蛋白水平的合子。所述方法和组合物可用于改善体外受精和胚胎移植方法以及核移植技术。

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