首页> 外国专利> VACCINE AGAINST STREPTOCOCCUS AGALACTIAE INFECTION USING NATIVE OR RECOMBINANT S. AGALACTIAE GLYCERALDHEYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) AS A TARGET ANTIGEN

VACCINE AGAINST STREPTOCOCCUS AGALACTIAE INFECTION USING NATIVE OR RECOMBINANT S. AGALACTIAE GLYCERALDHEYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) AS A TARGET ANTIGEN

机译：使用天然或重组的无乳链球菌甘油醛二磷酸3-磷酸脱氢酶（GAPDH）作为靶抗原，预防链球菌无乳杆菌感染的疫苗。

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摘要

The present invention regards a vaccine against Streptococcus agalactiae infection, a leading cause of neonatal pneumonia, sepsis and meningitis. The vaccine is composed by glyceraldheyde-3-phosphate dehydrogenase (GAPDH) protein obtained from culture supernatants of S. agalactiae cells, or by recombinant GAPDH (rGAPDH) obtained from the gene coding for the S. agalactiae GAPDH cloned and expressed in a heterologous system. The vaccine administered in a submitogenic dose of GAPDH, or rGAPDH, protects the host against S. agalactiae infection. Vaccination is used as a preventive approach and is administered by intravenous and/or intradermic and/or subcutaneous and/or mucosal route. Therefore, the invention field is in the area of the pharmaceutical industry.

机译：本发明涉及针对无乳链球菌感染的疫苗，无乳链球菌感染是新生儿肺炎，败血症和脑膜炎的主要原因。该疫苗由从I培养物上清液中获得的3-磷酸甘油醛脱氢酶（GAPDH）蛋白质组成。无乳细胞，或通过重组GAPDH（rGAPDH）从编码 S的基因获得。无乳 GAPDH克隆并在异源系统中表达。以顺应性剂量的GAPDH或rGAPDH施用的疫苗可保护宿主免受I。无乳感染。疫苗接种被用作预防方法，并通过静脉内和/或皮内和/或皮下和/或粘膜途径施用。因此，本发明领域是制药工业领域。 展开▼

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公开/公告号US2009269826A1

专利类型

公开/公告日2009-10-29

原文格式PDF

申请/专利权人 PAULA MARIA DAS NEVES FERREIRA DA SILVA;MARIA DELFINA DA CONCEIÇÃO TAVARES GOMES;PATRICK TRIEU-CUOT;MANUEL JOÃO RUA VILANOVA;MARINA DE BARROS NASCIMENTO BAPTISTA;
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申请/专利号US20070282749

发明设计人 MARINA DE BARROS NASCIMENTO BAPTISTA;MARIA DELFINA DA CONCEIÇÃO TAVARES GOMES;PATRICK TRIEU-CUOT;PAULA MARIA DAS NEVES FERREIRA DA SILVA;MANUEL JOÃO RUA VILANOVA;
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申请日2007-03-13

分类号C12N9/02;

国家 US

入库时间 2022-08-21 19:34:41

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1. 基于pgk基因的重组乳酸乳球菌和无乳链球菌病疫苗 [P] . 中国专利： CN110669711A . 2020-01-10

2. 重组乳酸乳球菌和罗非鱼无乳链球菌病疫苗 [P] . 中国专利： CN110669710A . 2020-01-10

3. VACCINE AGAINST STREPTOCOCCUS AGALACTIAE INFECTION USING NATIVE OR RECOMBINANT S. AGALACTIAE GLYCERALDHEYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) AS A TARGET ANTIGEN [P] . 世界知识产权组织专利： WO2007105169B1 . 2008-01-24

机译：使用天然或重组的无乳链球菌甘油醛二磷酸3-磷酸脱氢酶（GAPDH）作为靶抗原，预防链球菌无乳杆菌感染的疫苗。

4. VACCINE AGAINST STREPTOCOCCUS AGALACTIAE INFECTION USING NATIVE OR RECOMBINANT S. AGALACTIAE GLYCERALDHEYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) AS A TARGET ANTIGEN [P] . 欧洲知识产权局专利： EP2001506A2 . 2008-12-17

机译：使用天然或重组的无乳链球菌甘油醛二磷酸3-磷酸脱氢酶（GAPDH）作为靶抗原，预防链球菌无乳杆菌感染的疫苗。

5. VACCINE AGAINST STREPTOCOCCUS AGALACTIAE INFECTION USING NATIVE OR RECOMBINANT S. AGALACTIAE GLYCERALDHEYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH) AS A TARGET ANTIGEN [P] . 世界知识产权组织专利： WO2007105169A3 . 2007-11-15

机译：使用天然或重组的无乳链球菌甘油醛二磷酸3-磷酸脱氢酶（GAPDH）作为靶抗原，预防链球菌无乳杆菌感染的疫苗。

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6. 皮下免疫磷酸甘油醛脱氢酶(GAPDH)对小鼠肺炎链球菌感染的保护效果和机制研究 [A] . 孙潇雨 . 2017