首页> 外国专利> PROTEIN, OSTEOCLAST DIFFERENTIATION INHIBITOR, INFLAMMATORY BONE RESORPTION THERAPEUTIC AGENT, GENE, RECOMBINANT VECTOR, METHOD OF MANUFACTURING A PROTEIN, METHOD OF INHIBITING OSTEOCLAST DIFFERENTIATION, AND METHOD OF TREATING INFLAMMATORY BONE RESORPTION

PROTEIN, OSTEOCLAST DIFFERENTIATION INHIBITOR, INFLAMMATORY BONE RESORPTION THERAPEUTIC AGENT, GENE, RECOMBINANT VECTOR, METHOD OF MANUFACTURING A PROTEIN, METHOD OF INHIBITING OSTEOCLAST DIFFERENTIATION, AND METHOD OF TREATING INFLAMMATORY BONE RESORPTION

机译：蛋白质，破骨细胞分化抑制剂，炎性骨再吸收治疗剂，基因，重组载体，蛋白质的制备方法，抑制破骨细胞分化的方法以及治疗炎症性骨再形成的方法

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摘要

There are provided a protein which comprises the amino acid sequence of an extracellular region of Ror2 and is water-soluble, an osteoclast differentiation inhibitor for inhibiting differentiation of a precursor cell of osteoclast into an osteoclast, which comprises the protein as described above, an inflammatory bone resorption therapeutic agent for treating inflammatory bone resorption, which comprises the protein as described above, a gene which codes a protein comprising the amino acid sequence of an extracellular region of Ror2 and being water-soluble, a recombinant vector which comprises the gene as described above, a method of manufacturing a protein, which comprises a step of causing expression of a gene coding a protein comprising the amino acid sequence of an extracellular region of Ror2 and being water-soluble in a microorganism to synthesize the protein and a step of extracting the protein from the microorganism into water or an aqueous solution, a method of inhibiting osteoclast differentiation, which uses the protein as described above, and a method of treating inflammatory bone resorption, which uses a protein as described above.

机译：提供了一种蛋白质，其包含Ror2的细胞外区域的氨基酸序列并且是水溶性的，用于抑制破骨细胞的前体细胞向破骨细胞分化的破骨细胞分化抑制剂，其包含上述蛋白质，一种用于治疗炎性骨吸收的骨吸收治疗剂，其包含上述蛋白质，编码包含Ror2的细胞外区域的氨基酸序列且为水溶性的蛋白质的基因，包含上述基因的重组载体。如上所述，一种蛋白质的制造方法，其包括使编码包含Ror2的细胞外区域的氨基酸序列的蛋白质的基因表达并在微生物中水溶性以合成该蛋白质的步骤和提取步骤。将微生物中的蛋白质转化为水或水溶液的一种抑制渗透的方法破骨细胞分化，其使用如上所述的蛋白质，以及治疗炎性骨吸收的方法，其使用如上所述的蛋白质。

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公开/公告号US2009074742A1

专利类型
公开/公告日2009-03-19

原文格式PDF
申请/专利权人 YASUHIRO KOBAYASHI;
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申请/专利号US20080175217
发明设计人 YASUHIRO KOBAYASHI;
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申请日2008-07-17
分类号C07K14/435;C12N15/12;C12N15/54;C12P21/02;C12N5/06;C12N15/85;A61K38/17;A61K38/45;A61P19;
国家 US
入库时间 2022-08-21 19:35:00

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