首页> 外国专利> NANOPARTICLES WITH LIPID CORE AND POLYMER SHELL STRUCTURES FOR PROTEIN DRUG DELIVERY PREPARED BY NANOENCAPSULATION

NANOPARTICLES WITH LIPID CORE AND POLYMER SHELL STRUCTURES FOR PROTEIN DRUG DELIVERY PREPARED BY NANOENCAPSULATION

机译:纳米胶囊制备的脂质核心和聚合物壳结构的纳米颗粒用于蛋白质药物的递送

摘要

The present invention relates to an application of stabilized nanoparticles with a lipid core and shell structures as protein drug carriers, wherein the nanoparticles are prepared by producing nano-sized particles from lecithin obtained from natural soybean, and then adsorbing polaxamer thereon. Here, lecithin is used as an ingredient of core structure, polaxamer is used as an ingredient of shell structure, and both ingredients are applicable to a human body. Thus-obtained nanoparticles having a lipid core and shell structures are applicable in the clinical application. Moreover, said nanoparticles are suitable for use as a drug carrier or a diagnostic agent because they are produced in an aqueous solution without organic solvents.
机译:本发明涉及具有脂质核和壳结构的稳定化的纳米颗粒作为蛋白质药物载体的应用,其中所述纳米颗粒通过以下方法制备:通过从天然大豆获得的卵磷脂制备纳米尺寸的颗粒,然后在其上吸附泊拉沙姆。在此,卵磷脂用作核心结构的成分,泊拉沙姆用作壳结构的成分,并且两种成分都适用于人体。如此获得的具有脂质核和壳结构的纳米颗粒可应用于临床。此外,所述纳米颗粒适合于用作药物载体或诊断剂,因为它们在没有有机溶剂的水溶液中产生。

著录项

  • 公开/公告号US2009214633A1

    专利类型

  • 公开/公告日2009-08-27

    原文格式PDF

  • 申请/专利权人 SOON-HONG YUK;KEUN-SANG OH;

    申请/专利号US20060296100

  • 发明设计人 KEUN-SANG OH;SOON-HONG YUK;

    申请日2006-12-01

  • 分类号A61K9/127;A61K38/16;

  • 国家 US

  • 入库时间 2022-08-21 19:36:21

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